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Small CERN detector for more precise radiotherapy

Small CERN detector for more precise radiotherapy

Technology News |
By Wisse Hettinga



Scientists are testing a new device to help target cancer cells more accurately in ion radiotherapy of head and neck tumours, which could help limit the treatment’s side effects. It includes Timepix3, a small particle detector developed at CERN

From the CERN website:

Particle detectors like the ones used by physicists at CERN can have wide applications beyond fundamental research. Scientists from the German National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and the Heidelberg Ion Beam Therapy Center (HIT) at Heidelberg University Hospital are now testing a new imaging device supplied by the Czech company ADVACAM on its first patients. The device, which includes a small Timepix3 pixel detector developed at CERN, allows head and neck tumours to be closely monitored during ion radiotherapy, making them easier to target and thus helping limit the treatment’s side effects.

“One of the most advanced methods for treating head and neck tumours involves irradiation with ion beams. This has one unique feature: it can be precisely tailored to the depth inside the human head where the particles should have the maximal effect”, explains Mária Martišíková, the head of the DKFZ team.

Yet like other types of irradiation, ion radiation also has a drawback. The particle beams affect not only the tumour but also part of the healthy tissue around it. This is particularly challenging in the brain, where damage to the optic nerve or a patient’s memory are possible. Ideally, the irradiated area around the tumour should be as small as possible, and the dose to the tumour should be as high as possible. However, current technology does not allow for sufficiently precise targeting of the ions.

To complicate matters further, the situation inside a patient’s head can change during therapy. The x-ray computed tomography (CT) scan image taken before treatment is essentially used as a “map” to target the tumour with ion beams. But during therapy, the situation inside the skull may evolve. Until now, physicians lacked a reliable tool to alert them in case of a change in the brain.

The new ADVACAM device could help solve these issues, by improving the navigation of the ion beams inside the head by tracking the secondary particles that are created when ions pass through it …

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