Arrays of U-shaped nanowire field-effect transistors probe neurons: Page 2 of 2

July 04, 2019 //By Julien Happich
neurons
The ability to read electrical activities from cells is the foundation of many biomedical procedures, such as brain activity mapping and neural prosthetics.

Our ultra-small, flexible, nanowire probes could be a very powerful tool as they can measure intracellular signals with amplitudes comparable with those measured with patch clamp techniques; with the advantage of the device being scalable, it causes less discomfort and no fatal damage to the cell (cytosol dilation). Through this work, we found clear evidence for how both size and curvature affect device internalisation and intracellular recording signal”, commented Dr Yunlong Zhao from the Advanced Technology Institute at the University of Surrey, lead author of the article.

“This work represents a major step towards tackling the general problem of integrating ‘synthesized’ nanoscale building blocks into chip and wafer scale arrays, and thereby allowing us to address the long-standing challenge of scalable intracellular recording” added co-author Professor Charles Lieber from the Department of Chemistry and Chemical Biology at Harvard University.

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